The Bailey-Serres group performs translational plant biology from gene to field. We aim to harness genetic mechanisms that provide climate change resilience to crops, particularly flooding, drought and and nutrient stress resilience. We work from the single cell to whole plant level. Our studies have defined mechanisms of low oxygen sensing and post-transcriptional gene regulation, from the epigenome to the "mRNPome" and translatome. This knowledge is of importance to efforts that seek to stabilize crop yields as Earth’s population grows, arable land decreases, and climatic patterns change.
Our group is dedicated to promoting science education and professional development as well as fostering diversity and innovation in collaborative and interdisciplinary research.
Farmers of Bangladesh and India risk losing all or part of their rice crops each year to Monsoon floods. Fortunately, flood-resilient rice has become a reality due to the identification of a rice gene called SUB1A that allows vegetative stage plants to survive prolonged period of time underwater. New rice varieties have been bred for submergence tolerance and provided to farmers, primarily through the initiatives of the International Rice Research Institute. Our team has elucidated the complex mechanisms of function of the SUB1A gene.
Transcription and Beyond
To define low oxygen sensing and response mechanisms that enable survival for a short period of oxygen deprivation in the model plant Arabidopsis, we have studied extensively the regulation of gene expression that occurs after a gene transcript is produced, as the modulation of mRNA translation and storage provides a means to conserve energy when cells are deprived of oxygen.
Our group developed the method "Translating Ribosome Affinity Purification" (TRAP) that enables researchers to monitor the mRNAs undergoing translation by ribosomes (The Translatome). This method can be used to monitor gene activity in specific cells and developmentally defined regions of plants. We have promoted use of TRAP and INTACT for multi-scale and cell type specific gene regulation analysis in crops.
Bailey-Serres, J., Parker, J.E., Ainsworth, E.A. et al. Genetic strategies for improving crop yields. Nature 575, 109–118 (2019) doi:10.1038/s41586-019-1679-0 in the 150 years of Nature reviews collection.
Reynoso, Kajala, Bajic, West, Pauluzzi et al. Science (link below). This is the NSF PGR funded "Plasticity Project" team's deep genomic study comparing root tip gene regulatory networks responding to submergence responses in rice, medicago, tomato and a wild tomato. Resources on our Data page.
Travis Lee and Julia Bailey-Serres; The Plant Cell. A deep study of nuclear gene regulatory processes in response to hypoxia and re-aeration in Arabidopsis. See chromtin, RNAPII, ATAC-seq, and four different popultions or mRNA for your favorite gene in a browser: Data page.
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